Preheat your oven to 350°F (175°C). Grease a 9×5-inch loaf pan and line it with parchment paper.

In a large mixing bowl, whisk together the flour, sugar, baking powder, baking soda, and salt until evenly combined.

In another bowl, whisk together the orange juice, milk, egg, oil (or melted butter), and vanilla extract. Add the orange zest if including.

Gradually pour the wet mixture into the dry ingredients, stirring gently until just combined. Avoid overmixing.

Fold in the cranberries and nuts gently yet thoroughly.

Pour the batter into the prepared loaf pan, smoothing the top. Bake for 50-60 minutes or until a toothpick inserted in the center comes out clean.

Remove the loaf from the oven and let it cool in the pan for 10-15 minutes. Transfer it to a wire rack to cool completely.

While the loaf cools, whisk together the powdered sugar and orange juice to make a smooth glaze.

Drizzle the glaze over the cooled loaf, slice, and enjoy!